Please Note:
These medications do *not* reverse the disorder.
Other than nutritional adjustments, possible treatments for Mega-E symptoms include the motility drug Cisapride, H2 blockers, PPIs (hydrogen proton pump inhibitors) & antibiotics to hopefully alleviate or reduce regurgitation, ulcerations, esophagitis, and aspiration pneumonia.
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Carafate (Sucrafalate) (cyto-protective 'bandage' against ulceration -- esophagitis. Please note, Carafate may interfere with other meds. absorption rate & should not be used in a dog experiencing reduced kidney function.)
Metoclopramide (Reglan) works as an anti-emitic, also modifying motility.
Cisapride (Prepulsid) is Used Less Frequently (to hopefully increase lower esophageal sphincter (LES) tone & motility -- *** can make some dogs' regurgitation worse due to LES tightening).
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PPI - Proton Pump Inhibitors -- PPIs are more potent acid blockers than those of the H-2 class (see list below). PPIs block production of acid & relieve irritated tissue. PPIs are:
Omeprazole is Prilosec Rabeprazole is Aciphex
Iansoprazole is Prevacid Pantoprazole is Protonix
Esomeprazole is Nexium
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H-2 Receptor Blockers -- Typically less expensive but they are also weaker than PPIs.
Nizatidine is Axid
Ranitidine is Zantac
Famotidine is Pepcid
Cimetidine is Tagamet HB
Footnote: From a study, " Cimetidine was significantly effective in preventing ulcer relapse (p < 0.01), however Cysteine and MMSC were more effective in this respect (p < 0.05)." Learn more (footnote of page).
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Other Resources:
Veterinary Partner: http://www.veterinarypartner.com/ (use search function)
Merck – Prokinetic Gastrointestinal Drugs http://www.merckvetmanual.com/mvm/index.jsp?cfile=htm/bc/190307.htm
Medications
